Article
Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population.
The Journal of infectious diseases - 15 Nov 2002
Li Cheuk M, Campbell Sarah J, Kumararatne Dinakantha S, Bellamy Richard, Ruwende Cyril, McAdam Keith P W J, Hill Adrian V S, Lammas David A
Abstract excerpt
Adenosine triphosphate (ATP) ligation of P2X(7) receptors expressed on human macrophages that are infected with mycobacteria induces cell death and subsequent loss of intracellular bacterial viability. Marked heterogeneity observed in cell donor ATP responsiveness suggests that this antimycobacte...
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