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Article

P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2010

Lees Michael P, Fuller Stephen J, McLeod Rima, Boulter Nicola R, Miller Catherine M, Zakrzewski Alana M, Mui Ernest J, Witola William H, Coyne Jessica J, Hargrave Aubrey C, Jamieson Sarra E, Blackwell Jenefer M, Wiley James S, Smith Nicholas C

Abstract excerpt

The P2X7R is highly expressed on the macrophage cell surface, and activation of infected cells by extracellular ATP has been shown to kill intracellular bacteria and parasites. Furthermore, single nucleotide polymorphisms that decrease receptor function reduce the ability of human macrophages to...

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Identifiers

PMID: 20488797
DOI: 10.4049/jimmunol.1000012
PMCID: PMC2931343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20488797-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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