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Article

Gene dosage determines the negative effects of polymorphic alleles of the P2X7 receptor on adenosine triphosphate-mediated killing of mycobacteria by human macrophages.

The Journal of infectious diseases - 1 Jul 2005

Fernando Suran L, Saunders Bernadette M, Sluyter Ronald, Skarratt Kristen K, Wiley James S, Britton Warwick J

Abstract excerpt

BACKGROUND: Stimulation of the P2X7 purinergic receptor (P2X7) in bacille Calmette-Guerin (BCG)-infected human macrophages with extracellular adenosine triphosphate (ATP) leads to pore formation and killing of mycobacteria. We examined the effect of polymorphisms in the P2X7 gene (P2X7) on the capacity of macrophages to kill mycobacteria. METHODS: Polymorphisms and mutations in P2X7 were identified by both DNA...

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Identifiers

PMID: 15942904
DOI: 10.1086/430622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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