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Article

A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis.

American journal of respiratory and critical care medicine - 15 Feb 2007

Fernando Suran L, Saunders Bernadette M, Sluyter Ronald, Skarratt Kristen K, Goldberg Hazel, Marks Guy B, Wiley James S, Britton Warwick J

Abstract excerpt

RATIONALE: Genetic variation influences susceptibility to clinical tuberculosis (TB). Activation of the P2X(7) receptor on human macrophages induces killing of mycobacteria. We have identified polymorphisms in the P2X(7) gene that markedly reduce this killing. OBJECTIVE: To determine if polymorphisms in P2X7 are associated with increased risk of TB, the prevalence of four polymorphisms was assessed in individuals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17095747
DOI: 10.1164/rccm.200607-970OC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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