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Article

A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2003

Saunders Bernadette M, Fernando Suran L, Sluyter Ronald, Britton Warwick J, Wiley James S

Abstract excerpt

Protective immunity to mycobacterial infections requires activation of the antibacterial mechanisms of infected macrophages. It has previously been reported that ATP treatment of mycobacteria-infected macrophages induces apoptosis mediated via the P2X(7) pathway and that this leads to the death of both the host cell and the internalized bacilli. We have recently identified a single nucleotide polymorphism in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14607949
DOI: 10.4049/jimmunol.171.10.5442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria.PMID 14607949Read ↗

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