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Ntg1p, the base excision repair protein, generates mutagenic intermediates in yeast mitochondrial DNA.

DNA repair - 13 Jul 2006

Phadnis Naina, Mehta Reema, Meednu Nida, Sia Elaine A

Abstract excerpt

Mitochondrial DNA is predicted to be highly prone to oxidative damage due to its proximity to free radicals generated by oxidative phosphorylation. Base excision repair (BER) is the primary repair pathway responsible for repairing oxidative damage in nuclear and mitochondrial genomes. In yeast mitochondria, three N-glycosylases have been identified so far, Ntg1p, Ogg1p and Ung1p. Ntg1p, a broad specificity...

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Identifiers

PMID: 16730479
DOI: 10.1016/j.dnarep.2006.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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