Article
Internal tandem duplication and Asp835 mutations of the FMS-like tyrosine kinase 3 (FLT3) gene in acute promyelocytic leukemia.
Cancer - 15 Sept 2003
Shih Lee-Yung, Kuo Ming-Chung, Liang Der-Cherng, Huang Chein-Fuang, Lin Tung-Liang, Wu Jin-Hou, Wang Po-Nan, Dunn Po, Lai Chang-Liang
Abstract excerpt
BACKGROUND: The clinical relevance of mutations of the FMS-like tyrosine kinase 3 (FLT3) gene in specific cytogenetic subgroups is not clear. The authors examined internal tandem duplication (ITD) and Asp835 mutations of FLT3 in patients with acute promyelocytic leukemia (APL) to determine the incidence of these mutations and to analyze the results for correlations with clinicohematologic features and outcome....
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