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Article

A genetic analysis of interactions with Spc110p reveals distinct functions of Spc97p and Spc98p, components of the yeast gamma-tubulin complex.

Molecular biology of the cell - 1 Aug 1998

Nguyen T, Vinh D B, Crawford D K, Davis T N

Abstract excerpt

The spindle pole body (SPB) in Saccharomyces cerevisiae functions as the microtubule-organizing center. Spc110p is an essential structural component of the SPB and spans between the central and inner plaques of this multilamellar organelle. The amino terminus of Spc110p faces the inner plaque, the substructure from which spindle microtubules radiate. We have undertaken a synthetic lethal screen to identify...

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Identifiers

PMID: 9693376
DOI: 10.1091/mbc.9.8.2201
PMCID: PMC25473

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A genetic analysis of interactions with Spc110p reveals distinct functions of Spc97p and Spc98p, components of the yeast gamma-tubulin complex.PMID 9693376Read ↗

A mutational analysis identifies three functional regions of the spindle pole component Spc110p in Saccharomyces cerevisiae.Semantic proximity Read ↗

The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication.Semantic proximity Read ↗

The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment.Semantic proximity Read ↗

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Spc110p: assembly properties and role in the connection of nuclear microtubules to the yeast spindle pole body.Semantic proximity Read ↗

Analysis of a spindle pole body mutant reveals a defect in biorientation and illuminates spindle forces.Semantic proximity Read ↗

The 110-kD spindle pole body component of Saccharomyces cerevisiae is a phosphoprotein that is modified in a cell cycle-dependent manner.Semantic proximity Read ↗

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Mutational analysis reveals a role for the C terminus of the proteasome subunit Rpt4p in spindle pole body duplication in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p.Semantic proximity Read ↗

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