Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell Proliferation

4 Jan 2018

Abstract excerpt

Overactive p53 has been proposed as an important pathophysiological factor for bone marrow failure syndromes, including Fanconi anemia (FA). Here, we report a p53-dependent effect on hematopoietic stem and progenitor cell (HSPC) proliferation in mice deficient for the FA gene Fanca . Deletion of p53 in Fanca −/− mice leads to replicative exhaustion of the hematopoietic stem cell (HSC) in transplant recipients....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29307578
DOI: 10.1016/j.stemcr.2017.12.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell ProliferationPMID 29307578Read ↗

Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic StrategiesSemantic proximity Read ↗

Fanconi anemia type C-deficient hematopoietic stem/progenitor cells exhibit aberrant cell cycle control.Semantic proximity Read ↗

Recent advances in understanding hematopoiesis in Fanconi AnemiaSemantic proximity Read ↗

Impairment of fetal hematopoietic stem cell function in the absence of Fancd2.Semantic proximity Read ↗

[Fanconi anemia--genotoxic stress and senescence of hematopoietic stem cells].Semantic proximity Read ↗

The p53 tumor suppressor protein regulates hematopoietic stem cell fateSemantic proximity Read ↗

Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation.Semantic proximity Read ↗

The p53 pathway in hematopoiesis: lessons from mouse models, implications for humansSemantic proximity Read ↗

The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC.Semantic proximity Read ↗

A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-RenewalSemantic proximity Read ↗

ZMAT3 alleviates cell death of Fanconi Anemia deficient cells by modulating sphingolipid metabolism and ferroptosis.Semantic proximity Read ↗

In Utero Hematopoietic Stem Cell Transplant for Fanconi AnemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.