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Article

p53-dependent pathway of radio-induced apoptosis is altered in Fanconi anemia.

Oncogene - 5 Jan 1995

Rosselli F, Ridet A, Soussi T, Duchaud E, Alapetite C, Moustacchi E

Abstract excerpt

Fanconi anemia belongs to a group of human genetic diseases characterized by chromosomal instability, sensitivity to genotoxic agents associated to impaired processing of DNA lesions, cell cycle anomalies and cancer predisposition. We recently added to this list of distinctive features reduced production of interleukin 6 and overproduction of tumor necrosis factor alpha. Since growth factor deprivation, TNF alpha...

Topics

Cell Cycle
Cells, Cultured
Fanconi Anemia
Genes, p53
Humans
Lymphocytes
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7824283

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7824283-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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