Tumor necrosis factor-alpha polymorphism, bone strength phenotypes, and the risk of fracture in older women.

doi:10.1210/jc.2004-2235

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Article

Tumor necrosis factor-alpha polymorphism, bone strength phenotypes, and the risk of fracture in older women.

The Journal of clinical endocrinology and metabolism - 1 Jun 2005

Moffett S P, Zmuda J M, Oakley J I, Beck T J, Cauley J A, Stone K L, Lui Li-Yung, Ensrud K E, Hillier T A, Hochberg M C, Morin P, Peltz G, Greene D, Cummings S R

Abstract excerpt

TNFalpha is a proinflammatory cytokine that promotes osteoclastic bone resorption. We evaluated the association between a G-308A polymorphism (rs1800629) at the TNFA locus and osteoporosis phenotypes in 4306 older women participating in the Study of Osteoporotic Fractures. Femoral neck bone mineral density (BMD) and structural geometry were measured using dual-energy x-ray absorptiometry and hip structural...

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PMID: 15797957
DOI: 10.1210/jc.2004-2235

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