Article
Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme.
Molecular and cellular biology - 1 Mar 1997
Shi X, Chang M, Wolf A J, Chang C H, Frazer-Abel A A, Wade P A, Burton Z F, Jaehning J A
Abstract excerpt
The products of the yeast CDC73 and PAF1 genes were originally identified as RNA polymerase II-associated proteins. Paf1p is a nuclear protein important for cell growth and transcriptional regulation of a subset of yeast genes. In this study we demonstrate that the product of CDC73 is a nuclear protein that interacts directly with purified RNA polymerase II in vitro. Deletion of CDC73 confers a...
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