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Article

Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.

The Journal of biological chemistry - 20 Dec 2002

Watanabe Reika, Funato Kouichi, Venkataraman Krishnan, Futerman Anthony H, Riezman Howard

Abstract excerpt

Ongoing sphingolipid synthesis is specifically required in vivo for the endoplasmic reticulum (ER) to Golgi transport of glycosylphosphatidylinositol (GPI)-anchored proteins. However, the sphingolipid intermediates that are required for transport nor their role(s) have been identified. Using stereoisomers of dihydrosphingosine, together with specific inhibitors and a mutant defective for sphingolipid synthesis,...

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Source

Identifiers

PMID: 12393888
DOI: 10.1074/jbc.M206209200

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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