Article
Fatty acid remodeling of GPI-anchored proteins is required for their raft association.
Molecular biology of the cell - 1 Apr 2007
Maeda Yusuke, Tashima Yuko, Houjou Toshiaki, Fujita Morihisa, Yoko-o Takehiko, Jigami Yoshifumi, Taguchi Ryo, Kinoshita Taroh
Abstract excerpt
Whereas most of the cellular phosphatidylinositol (PI) contain unsaturated fatty chains and are excluded from rafts, GPI-anchored proteins (APs) unusually contain two saturated fatty chains in their PI moiety, and they are typically found within lipid rafts. However, the origin of the saturated chains and whether they are essential for raft association are unclear. Here, we report that GPI-APs, with two saturated...
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