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Article

Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast.

The EMBO journal - 15 Aug 1994

Horvath A, Sütterlin C, Manning-Krieg U, Movva N R, Riezman H

Abstract excerpt

Inhibition of ceramide synthesis by a fungal metabolite, myriocin, leads to a rapid and specific reduction in the rate of transport of glycosylphosphatidylinositol (GPI)-anchored proteins to the Golgi apparatus without affecting transport of soluble or transmembrane proteins. Inhibition of cerami...

Topics

Acyltransferases
Antifungal Agents
Biological Transport
Ceramides
Fatty Acids, Monounsaturated
Fungal Proteins
Glycosylphosphatidylinositols
Golgi Apparatus
Membrane Glycoproteins
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Serine C-Palmitoyltransferase

Sphingolipids

Source

Open in PubMed Open full text

Identifiers

PMID: 8070398
DOI: 10.1002/j.1460-2075.1994.tb06678.x
PMCID: PMC395279

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8070398-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast.PMID 8070398Read ↗

Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.Semantic proximity Read ↗

Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast.Semantic proximity Read ↗

Determination and physiological roles of the glycosylphosphatidylinositol lipid remodelling pathway in yeast.Semantic proximity Read ↗

Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity.Semantic proximity Read ↗

CWH43 is required for the introduction of ceramides into GPI anchors in Saccharomyces cerevisiae.Semantic proximity Read ↗

Generating anchors only to lose them: The unusual story of glycosylphosphatidylinositol anchor biosynthesis and remodeling in yeast and fungi.Semantic proximity Read ↗

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Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose.Semantic proximity Read ↗

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