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Article

Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast.

The EMBO journal - 15 Aug 1994

Horvath A, Sütterlin C, Manning-Krieg U, Movva N R, Riezman H

Abstract excerpt

Inhibition of ceramide synthesis by a fungal metabolite, myriocin, leads to a rapid and specific reduction in the rate of transport of glycosylphosphatidylinositol (GPI)-anchored proteins to the Golgi apparatus without affecting transport of soluble or transmembrane proteins. Inhibition of ceramide biosynthesis also quickly blocks remodelling of GPI anchors to their ceramide-containing, mild base-resistant forms....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 8070398
DOI: 10.1002/j.1460-2075.1994.tb06678.x
PMCID: PMC395279

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast.PMID 8070398Read ↗

Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.Semantic proximity Read ↗

Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast.Semantic proximity Read ↗

Determination and physiological roles of the glycosylphosphatidylinositol lipid remodelling pathway in yeast.Semantic proximity Read ↗

Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity.Semantic proximity Read ↗

CWH43 is required for the introduction of ceramides into GPI anchors in Saccharomyces cerevisiae.Semantic proximity Read ↗

Generating anchors only to lose them: The unusual story of glycosylphosphatidylinositol anchor biosynthesis and remodeling in yeast and fungi.Semantic proximity Read ↗

Intracellular trafficking of ceramide by ceramide transfer protein.Semantic proximity Read ↗

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GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor.Semantic proximity Read ↗

Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose.Semantic proximity Read ↗

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