Article
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Nature neuroscience - 1 Jun 2006
Yanai Anat, Huang Kun, Kang Rujun, Singaraja Roshni R, Arstikaitis Pamela, Gan Lu, Orban Paul C, Mullard Asher, Cowan Catherine M, Raymond Lynn A, Drisdel Renaldo C, Green William N, Ravikumar Brinda, Rubinsztein David C, El-Husseini Alaa, Hayden Michael R
Abstract excerpt
Post-translational modification by the lipid palmitate is crucial for the correct targeting and function of many proteins. Here we show that huntingtin (htt) is normally palmitoylated at cysteine 214, which is essential for its trafficking and function. The palmitoylation and distribution of htt...
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