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Article

Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development.

Developmental biology - 15 Jan 2015

Sanders Shaun S, Hou Juan, Sutton Liza M, Garside Victoria C, Mui Katherine K N, Singaraja Roshni R, Hayden Michael R, Hoodless Pamela A

Abstract excerpt

Huntington disease (HD) is an adult-onset neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms that is caused by a CAG expansion in the HTT gene. Palmitoylation is the addition of saturated fatty acids to proteins by DHHC palmitoylacyl transferases. HTT is palmitoylated by huntingtin interacting proteins 14 and 14-like (HIP14 and HIP14L or ZDHHC17 and 13 respectively). Mutant HTT...

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Source

Identifiers

PMID: 25478910
DOI: 10.1016/j.ydbio.2014.11.018

Genes

HTT
ZDHHC17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development.PMID 25478910Read ↗

Aberrant palmitoylation in Huntington diseaseSemantic proximity Read ↗

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.Semantic proximity Read ↗

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Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicitySemantic proximity Read ↗

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.Semantic proximity Read ↗

Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport.Semantic proximity Read ↗

Memory and synaptic deficits in <i>Hip14/DHHC17</i> knockout miceSemantic proximity Read ↗

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Hypothesis: huntingtin may function in membrane association and vesicular traffickingThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease.Semantic proximity Read ↗

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