Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional inactivation of the SR family of splicing factors during a vaccinia virus infection.

EMBO reports - 1 Nov 2002

Huang Tien-sheng, Nilsson Camilla Estmer, Punga Tanel, Akusjarvi Goran

Abstract excerpt

SR proteins are essential splicing factors required for constitutive splicing and function as key regulators of alternative RNA splicing. We have shown that SR proteins purified from late adenovirus-infected cells (SR-Ad) are functionally inactivated as splicing enhancer or splicing repressor proteins by a virus-induced partial de-phosphorylation. Here, we show that SR proteins purified from late...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Gene Expression Regulation, Viral
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phosphorylation

Share to Repressor Proteins

Share to RNA-Binding Proteins

Share to RNA Splicing

Share to Vaccinia virus

Source

Open in PubMed Open full text

Identifiers

PMID: 12393754
DOI: 10.1093/embo-reports/kvf217
PMCID: PMC1307598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional inactivation of the SR family of splicing factors during a vaccinia virus infection.PMID 12393754Read ↗

Viral double-stranded RNAs from vaccinia virus early or intermediate gene transcripts possess PKR activating function, resulting in NF-kappaB activation, when the K1 protein is absent or mutated.Semantic proximity Read ↗

Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein.Semantic proximity Read ↗

Dynamic organization of splicing factors in adenovirus-infected cellsSemantic proximity Read ↗

Phosphorylation of vesicular stomatitis virus phosphoprotein P is indispensable for virus growth.Semantic proximity Read ↗

Control of retroviral RNA splicing through maintenance of suboptimal processing signals.Semantic proximity Read ↗

Vaccinia virus E10R protein is associated with the membranes of intracellular mature virions and has a role in morphogenesis.Semantic proximity Read ↗

Functional domain structure of human T-cell leukemia virus type 2 rex.Semantic proximity Read ↗

Temperature-sensitive mutations in the gene encoding the small subunit of the vaccinia virus early transcription factor impair promoter binding, transcription activation, and packaging of multiple virion components.Semantic proximity Read ↗

A novel type of splicing enhancer regulating adenovirus pre-mRNA splicing.Semantic proximity Read ↗

Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties.Semantic proximity Read ↗

Temperature-sensitive mutant in the vaccinia virus E6 protein produce virions that are transcriptionally inactive.Semantic proximity Read ↗

Pre-mRNA splicing in the absence of an SR protein RS domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.