Article
A novel type of splicing enhancer regulating adenovirus pre-mRNA splicing.
Molecular and cellular biology - 1 Apr 2000
Mühlemann O, Yue B G, Petersen-Mahrt S, Akusjärvi G
Abstract excerpt
Splicing of the adenovirus IIIa pre-mRNA is subjected to a temporal regulation, such that efficient IIIa 3' splice site usage is confined to the late phase of the infectious cycle. Here we show that IIIa pre-mRNA splicing is activated more than 200-fold in nuclear extracts prepared from late adenovirus-infected cells (Ad-NE) compared to uninfected HeLa cell nuclear extracts (HeLa-NE). In contrast, splicing of the...
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