Article
A new locus on chromosome 18 that influences normal variation in activated protein C resistance phenotype and factor VIII activity and its relation to thrombosis susceptibility.
Blood - 1 Jan 2003
Soria José Manuel, Almasy Laura, Souto Joan Carles, Buil Alfonso, Martinez-Sanchez Elisabeth, Mateo José, Borrell Montserrat, Stone William H, Lathrop Mark, Fontcuberta Jordi, Blangero John
Abstract excerpt
Activated protein C resistance (APCR) is the most prevalent risk factor for thrombosis, accounting for 20% to 60% of familial thrombophilia. A mutation in the F5 gene, factor V Leiden (FVL), is a major determinant of pathological APCR in some populations. However, APCR predicts risk for thrombosis independently of FVL. This suggests that other genetic factors may influence risk of thrombosis through quantitative...
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