Article
Association after linkage analysis indicates that homozygosity for the 46C-->T polymorphism in the F12 gene is a genetic risk factor for venous thrombosis.
Thrombosis and haemostasis - 1 May 2004
Tirado Isabel, Soria José Manuel, Mateo José, Oliver Artur, Souto Juan Carlos, Santamaria Amparo, Felices Rosa, Borrell Montserrat, Fontcuberta Jordi
Abstract excerpt
In a family-based study called GAIT (Genetic Analysis of Idiopathic Thrombophilia) that included a genome-wide scan we demonstrated that a polymorphism (46C-->T) in the F12 locus jointly influences variability of plasma (Factor XII) FXII levels and susceptibility to thrombotic disease. It then became germane to determine the prevalence of the 46C-->T polymorphism and its relative risk of thrombotic disease. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.