Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-15 enhances survival and function of HIV-specific CD8+ T cells

15 Jan 2003

Abstract excerpt

HIV-specific CD8(+) T cells are prone to undergo apoptosis, and this may affect their ability to control HIV infection. Because CD8-mediated immune responses play a key role in controlling HIV infection, enhancing the survival and effector function of HIV-specific CD8(+) T cells may augment their ability to control HIV virus. We show here that interleukin 15 (IL-15) potently inhibits spontaneous and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12393488
DOI: 10.1182/blood-2002-07-1957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-15 enhances survival and function of HIV-specific CD8+ T cellsPMID 12393488Read ↗

Trans-presentation of IL-15 modulates STAT5 activation and Bcl-6 expression in TH1 cellsSemantic proximity Read ↗

IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection.Semantic proximity Read ↗

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells.Semantic proximity Read ↗

Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.Semantic proximity Read ↗

Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex VivoSemantic proximity Read ↗

Expression of interleukin-15 and interleukin-15Rα in monocytes of HIV type 1-infected patients with different courses of disease progression.Semantic proximity Read ↗

CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosisSemantic proximity Read ↗

Antiviral CD4+ memory T cells are IL-15 dependent.Semantic proximity Read ↗

Immunogenetics of CD4 Lymphocyte Count Recovery during Antiretroviral Therapy: An AIDS Clinical Trials Group StudySemantic proximity Read ↗

IL-12 regulates the expansion, phenotype, and function of murine NK cells activated by IL-15 and IL-18.Semantic proximity Read ↗

The HIV latency reversal agent HODHBt enhances NK Cell effector and memory-like functions by increasing IL-15 mediated-STAT activationSemantic proximity Read ↗

Enhancement of HIV-1 Env-Specific CD8 T Cell Responses Using Interferon-Stimulated Gene 15 as an Immune Adjuvant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.