Article

The HIV latency reversal agent HODHBt enhances NK Cell effector and memory-like functions by increasing IL-15 mediated-STAT activation

2021-10-14

Abstract excerpt

Elimination of latent HIV reservoirs is a critical endpoint to eradicate HIV. One therapeutic intervention against latent HIV is ‘shock and kill’. This strategy is based on the transcriptional activation of latent HIV with a Latency-Reversing Agent (LRA) with the consequent killing of the reactivated cell by either the cytopathic effect of HIV or the immune system. We have previously found that the small molecule...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c7cd8a3-1c49-531a-b0ce-25ecc4c24846
DOI: 10.1101/2021.10.14.464348

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The HIV latency reversal agent HODHBt enhances NK Cell effector and memory-like functions by increasing IL-15 mediated-STAT activationDOI 10.1101/2021.10.14.464348Read

Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex VivoSemantic proximity Read

Isotretinoin promotes elimination of translation-competent HIV latent reservoirs in CD4T cellsSemantic proximity Read

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversalSemantic proximity Read

Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy?Semantic proximity Read

IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection.Semantic proximity Read

A broad drug arsenal to attack a strenuous latent HIV reservoirSemantic proximity Read

A New Small-Molecule Compound, Q308, Silences Latent HIV-1 Provirus by Suppressing Tat- and FACT-Mediated TranscriptionSemantic proximity Read

The Current Status of Latency Reversing Agents for HIV-1 RemissionSemantic proximity Read

Diverse Impacts of HIV Latency-Reversing Agents on CD8+ T-Cell Function: Implications for HIV CureSemantic proximity Read

Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat.Semantic proximity Read

The role of latency reversal in HIV cure strategiesSemantic proximity Read

Current Status of Latency Reversing Agents Facing the Heterogeneity of HIV-1 Cellular and Tissue ReservoirsSemantic proximity Read