Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.

Frontiers of medicine - 1 Sept 2012

Hatlen Megan A, Wang Lan, Nimer Stephen D

Abstract excerpt

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%-12% of adult and 12%-30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been gained from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 21
Share to Chromosomes, Human, Pair 8
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Oncogene Proteins, Fusion

Share to RUNX1 Translocation Partner 1 Protein

Share to Translocation, Genetic

Source

Identifiers

PMID: 22875638
DOI: 10.1007/s11684-012-0206-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.PMID 22875638Read ↗

t(8;21) Acute Myeloid Leukemia as a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming.Semantic proximity Read ↗

Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcriptsSemantic proximity Read ↗

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations.Semantic proximity Read ↗

Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications.Semantic proximity Read ↗

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.Semantic proximity Read ↗

RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesisSemantic proximity Read ↗

RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesisSemantic proximity Read ↗

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cellsSemantic proximity Read ↗

RUNX1-ETO: Attacking the Epigenome for Genomic Instable LeukemiaSemantic proximity Read ↗

Identification of additional cytogenetic and molecular genetic abnormalities in acute myeloid leukaemia with t(8;21)/<i>AML1‐ETO</i>Semantic proximity Read ↗

p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced deathSemantic proximity Read ↗

Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.