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Article

The t(8;21) Fusion Protein Interferes with AML-1B-Dependent Transcriptional Activation

1 Apr 1995

Abstract excerpt

The AML-1/CBF beta transcription factor complex is targeted by both the t(8;21) and the inv(16) chromosomal alterations, which are frequently observed in acute myelogenous leukemia. AML-1 is a site-specific DNA-binding protein that recognizes the enhancer core motif TGTGGT. The t(8;21) translocation fuses the first 177 amino acids of AML-1 to MTG8 (also known as ETO), generating a chimeric protein that retains...

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PMID: 7891692
DOI: 10.1128/mcb.15.4.1974

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