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Article

p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death

1 Nov 2007

Abstract excerpt

Chromosomal translocation (8;21) is present in 10% to 15% of patients with acute myeloid leukemia. Expression of the AML1-ETO (AE) fusion protein alone is not sufficient to induce leukemia, but the nature of the additional genetic alterations is unknown. It is unclear whether AE facilitates acquisition of these cooperating events. We show that AE down-regulates genes involved in multiple DNA repair pathways,...

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Identifiers

PMID: 17975013
DOI: 10.1182/blood-2007-06-093682

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