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The AML1/ETO fusion protein activates transcription of BCL-2

26 Nov 1996

Abstract excerpt

The AML1 gene, located on chromosome 21, is involved in several distinct chromosomal translocations in human leukemia. In t(8;21) acute myelogenous leukemia (AML), the AML1 gene is juxtaposed to the ETO gene located on chromosome 8, generating an AML1/ETO fusion protein. Both AML1/ETO and the AML1 proteins recognize the same consensus DNA-binding motif (TGT/CGGT), which is found in the promoters of several genes...

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Identifiers

PMID: 8943060
DOI: 10.1073/pnas.93.24.14059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The AML1/ETO fusion protein activates transcription of BCL-2PMID 8943060Read ↗

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