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Article

Hematologic effects of inactivating the Ras processing enzyme Rce1.

Blood - 15 Mar 2003

Aiyagari Abigail L, Taylor Brigit R, Aurora Vikas, Young Stephen G, Shannon Kevin M

Abstract excerpt

Posttranslational processing of Ras proteins has attracted considerable interest as a potential target for anticancer drug discovery. Rce1 encodes an endoprotease that facilitates membrane targeting of Ras and other prenylated proteins by releasing the carboxyl-terminal 3 amino acids (ie, the -AAX of the CAAX motif). Homozygous Rce1 mutant embryos (Rce1(-/-)) die late in gestation. To characterize the role of...

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PMID: 12433685
DOI: 10.1182/blood-2002-07-2250

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