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Article

The Structure of HLA-B8 Complexed to an Immunodominant Viral Determinant: Peptide-Induced Conformational Changes and a Mode of MHC Class I Dimerization

1 Nov 2002

Abstract excerpt

EBV is a ubiquitous human pathogen that chronically infects up to 90% of the population. Persistent viral infection is characterized by latency and periods of viral replication that are kept in check by a strong antiviral CTL response. Despite the size of the EBV genome, CTL immunity focuses on only a few viral determinants but expands a large primary and memory response toward these epitopes. In unrelated...

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Identifiers

PMID: 12391232
DOI: 10.4049/jimmunol.169.9.5153

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Source receipt: pubmed, retrieved 7 Sept 2026.

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