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Article

Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens.

Scientific reports - 11 Jul 2017

Xiao Ziwei, Ye Zhiyong, Tadwal Vikeramjeet Singh, Shen Meixin, Ren Ee Chee

Abstract excerpt

Host CD8 T cell response to viral infections involves recognition of 8-10-mer peptides presented by MHC-I molecules. However, proteasomes generate predominantly 2-7-mer peptides, but the role of these peptides is largely unknown. Here, we show that single short peptides of <8-mer from Latent Membrane Protein 2 (LMP2) of Epstein Barr Virus (EBV) can bind HLA-A*11:01 and stimulate CD8+ cells. Surprisingly, two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28698575
DOI: 10.1038/s41598-017-05171-w
PMCID: PMC5505988

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