Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection

11 Feb 2020

Abstract excerpt

The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells, and molecular mimicry between foreign and self-peptides could promote T cell cross-reactivity. A pair of class I subtypes, HLA-B2705 and HLA-B2709, have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunotherapy and Immune Responses
Share to T-cell and B-cell Immunology
Share to Urticaria and Related Conditions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32117305
DOI: 10.3389/fimmu.2020.00179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell SelectionPMID 32117305Read ↗

Structure and immune recognition of HLA-B27 antigens: implications for disease association.Semantic proximity Read ↗

A single residue exchange between two HLA-B27 alleles triggers increased peptide flexibility.Semantic proximity Read ↗

Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA-B27 allotypes.Semantic proximity Read ↗

Antigen-specific immune reactions by expanded CD8+ T cell clones from HLA-B*27-positive patients with spondyloarthritisSemantic proximity Read ↗

HLA-B27: portraying immunodominant viral epitopes.Semantic proximity Read ↗

Thermodynamic and Structural Analysis of Peptide- and Allele-dependent Properties of Two HLA-B27 Subtypes Exhibiting Differential Disease AssociationSemantic proximity Read ↗

Dynamics of Ankylosing Spondylitis-associated Arthritogenic Peptide-MHC I interactionsSemantic proximity Read ↗

ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-EpitopesSemantic proximity Read ↗

Allele-dependent similarity between viral and self-peptide presentation by HLA-B27 subtypes.Semantic proximity Read ↗

Conformational Dimorphism of Self-peptides and Molecular Mimicry in a Disease-associated HLA-B27 SubtypeSemantic proximity Read ↗

Implications of structural and thermodynamic studies of HLA-B27 subtypes exhibiting differential association with ankylosing spondylitis.Semantic proximity Read ↗

Structural and dynamic features of HLA-B27 subtypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.