Article
Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex.
Molecular and cellular biology - 1 Nov 2002
Truscott Kaye N, Wiedemann Nils, Rehling Peter, Müller Hanne, Meisinger Chris, Pfanner Nikolaus, Guiard Bernard
Abstract excerpt
The mitochondrial intermembrane space contains a protein complex essential for cell viability, the Tim9-Tim10 complex. This complex is required for the import of hydrophobic membrane proteins, such as the ADP/ATP carrier (AAC), into the inner membrane. Different views exist about the role played by the Tim9-Tim10 complex in translocation of the AAC precursor across the outer membrane. For this report we have...
Topics
- Intracellular Membranes
- Macromolecular Substances
- Membrane Proteins
- Membrane Transport Proteins
- Mitochondria
- Mitochondrial ADP, ATP Translocases
- Mitochondrial Membrane Transport Proteins
- Mitochondrial Precursor Protein Import Complex Proteins