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Article

Domains of Pit-1 required for transcriptional synergy with GATA-2 on the TSH beta gene.

Molecular and cellular endocrinology - 31 Oct 2002

Gordon David F, Woodmansee Whitney W, Black Jennifer N, Dowding Janet M, Bendrick-Peart Jamie, Wood William M, Ridgway E Chester

Abstract excerpt

Previous studies showed that Pit-1 functionally cooperates with GATA-2 to stimulate transcription of the TSH beta gene. Pit-1 and GATA-2 are uniquely coexpressed in pituitary thyrotropes and activate transcription by binding to a composite promoter element. To define the domains of Pit-1 important for functional cooperativity with GATA-2, we cotransfected a set of Pit-1 deletions with an mTSH beta-luciferase...

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Identifiers

PMID: 12385825
DOI: 10.1016/s0303-7207(02)00223-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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