Article
A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone deficiency.
The Journal of clinical endocrinology and metabolism - 1 Aug 1996
Pellegrini-Bouiller I, Bélicar P, Barlier A, Gunz G, Charvet J P, Jaquet P, Brue T, Vialettes B, Enjalbert A
Abstract excerpt
The pituitary-specific transcription factor Pit-1/GHF1 regulates the expression of PRL, GH, and TSH beta genes through binding to specific regions of the promoters of these genes. Mutations of the Pit-1 gene have been shown to be responsible for a syndrome of combined pituitary hormone deficiency...
Topics
- Adolescent
- Adult
- Base Sequence
- Child
- DNA
- DNA-Binding Proteins
- Female
- Genes
- Genome
- Hormones
- Humans
- Magnetic Resonance Imaging
- Male
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Pedigree
- Pituitary Gland