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Article

Activities in Pit-1 determine whether receptor interacting protein 140 activates or inhibits Pit-1/nuclear receptor transcriptional synergy.

Molecular endocrinology (Baltimore, Md.) - 1 Aug 1997

Chuang F M, West B L, Baxter J D, Schaufele F

Abstract excerpt

Pituitary-specific transcription of the evolutionarily related rat (r) GH and PRL genes involves synergistic interactions between Pit-1 and other promoter-binding factors including nuclear receptors. We show that Pit-1/thyroid hormone receptor (TR) and Pit-1/estrogen receptor (ER) synergistic activation of the rGH and rPRL promoters are globally similar. Both synergies depend upon the same activation functions in...

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Source

Identifiers

PMID: 9259323
DOI: 10.1210/mend.11.9.9978

Genes

PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activities in Pit-1 determine whether receptor interacting protein 140 activates or inhibits Pit-1/nuclear receptor transcriptional synergy.PMID 9259323Read ↗

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A 5' distal palindrome within the mouse mammary tumor virus-long terminal repeat recruits a mammary gland-specific complex and is required for a synergistic response to progesterone plus prolactin.Semantic proximity Read ↗

Ras signaling and transcriptional synergy at a flexible Ets-1/Pit-1 composite DNA element is defined by the assembly of selective activation domains.Semantic proximity Read ↗

Domains of Pit-1 required for transcriptional synergy with GATA-2 on the TSH beta gene.Semantic proximity Read ↗

The pan-Pituitary Activator of Transcription, Ptx1 (Pituitary Homeobox 1), Acts in Synergy with SF-1 and Pit1 and Is an Upstream Regulator of the Lim-Homeodomain Gene Lim3/Lhx3Semantic proximity Read ↗

Selective constraints on the activation domain of transcription factor Pit-1.Semantic proximity Read ↗

Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors.Semantic proximity Read ↗

Basic science and clinical research advances in the pituitary transcription factors: Pit-1 and Prop-1.Semantic proximity Read ↗

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