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Article

Selective constraints on the activation domain of transcription factor Pit-1.

Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 1996

Majumdar S, Irwin D M, Elsholtz H P

Abstract excerpt

The POU transcription factor Pit-1 activates members of the prolactin/growth hormone gene family in specific endocrine cell types of the pituitary gland. Although Pit-1 is structurally conserved among vertebrate species, evolutionary changes in the pattern of Pit-1 RNA splicing have led to a notable "contraction" of the transactivation domain in the mammalian lineage, relative to Pit-1 in salmonid fish. By...

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Identifiers

PMID: 8816787
DOI: 10.1073/pnas.93.19.10256
PMCID: PMC38371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Selective constraints on the activation domain of transcription factor Pit-1.PMID 8816787Read ↗

A two-base change in a POU factor-binding site switches pituitary-specific to lymphoid-specific gene expression.Semantic proximity Read ↗

Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia.Semantic proximity Read ↗

The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain.Semantic proximity Read ↗

A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.Semantic proximity Read ↗

Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin.Semantic proximity Read ↗

A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone deficiency.Semantic proximity Read ↗

A mutation of the β-domain in POU1F1 causes pituitary deficiency due to dominant PIT-1β expression.Semantic proximity Read ↗

Basic science and clinical research advances in the pituitary transcription factors: Pit-1 and Prop-1.Semantic proximity Read ↗

Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors.Semantic proximity Read ↗

POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease*Semantic proximity Read ↗

Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency.Semantic proximity Read ↗

A Pit-1 threonine 220 phosphomimic reduces binding to monomeric DNA sites to inhibit Ras and estrogen stimulation of the prolactin gene promoter.Semantic proximity Read ↗

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