Article
Selective constraints on the activation domain of transcription factor Pit-1.
Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 1996
Majumdar S, Irwin D M, Elsholtz H P
Abstract excerpt
The POU transcription factor Pit-1 activates members of the prolactin/growth hormone gene family in specific endocrine cell types of the pituitary gland. Although Pit-1 is structurally conserved among vertebrate species, evolutionary changes in the pattern of Pit-1 RNA splicing have led to a nota...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Biological Evolution
- Conserved Sequence
- DNA-Binding Proteins
- Genetic Variation
- Mammals
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Pituitary Gland
- Protein Biosynthesis
- Rats
- Recombinant Proteins
- Salmon
- Transcription Factor Pit-1