Article
Pit-1 and pituitary function.
The Journal of pediatric endocrinology - 1 Jan 2000
Pfäffle R W, Parks J S, Brown M R, Heimann G
Abstract excerpt
Several patients with pituitary dwarfism and a variable degree of hypothyroidism have been shown to have mutations in their Pit-1 gene. Pit-1 activates transcription of the growth hormone and prolactin genes and is necessary for the control of the beta-TSH gene transcription. The various mutations have different effects on the DNA binding and transactivating properties of Pit-1. Multiple pituitary hormone...
Topics
- Animals
- DNA-Binding Proteins
- Humans
- Mutation
- Pituitary Gland
- Pituitary Hormones
- Transcription Factor Pit-1
- Transcription Factors