Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation analysis and mRNA expression of trail-receptors in human breast cancer.

International journal of cancer - 10 Nov 2002

Seitz Susanne, Wassmuth Peter, Fischer Jörg, Nothnagel Anita, Jandrig Burkhard, Schlag Peter M, Scherneck Siegfried

Abstract excerpt

The chromosome region 8p12-p22 shows frequent allelic loss in a variety of human malignancies, including breast cancer (BC). The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-receptors TRAIL-R1, -R2, -R3 and -R4 are located on 8p21-p22 and might be candidate tumor suppressor genes in this region. To evaluate the involvement of TRAIL receptors in breast carcinogenesis, we have analyzed the entire...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 8

Share to DNA Mutational Analysis

Share to Genes, p53

Share to Receptors, TNF-Related Apoptosis-Inducing Ligand

Share to Receptors, Tumor Necrosis Factor

Share to RNA, Messenger

Source

Identifiers

PMID: 12385006
DOI: 10.1002/ijc.10694

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation analysis and mRNA expression of trail-receptors in human breast cancer.PMID 12385006Read ↗

Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma.Semantic proximity Read ↗

Mutation of the DR5/TRAIL receptor 2 gene is infrequent in hepatocellular carcinoma.Semantic proximity Read ↗

Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer.Semantic proximity Read ↗

Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screeningSemantic proximity Read ↗

Caspase-8 regulation of TRAIL-mediated cell death.Semantic proximity Read ↗

Polymorphisms in TRAIL receptor genes and risk of breast cancer in Spanish women.Semantic proximity Read ↗

Frequent polymorphic changes but not mutations of TRAIL receptors DR4 and DR5 in mantle cell lymphoma and other B-cell lymphoid neoplasms.Semantic proximity Read ↗

Functional implication of TRAIL -716 C/T promoter polymorphism on its in vitro and in vivo expression and the susceptibility to sporadic breast tumor.Semantic proximity Read ↗

Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers.Semantic proximity Read ↗

Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma.Semantic proximity Read ↗

Comprehensive expression analysis of TNF-related apoptosis-inducing ligand and its receptors in colorectal cancer: Correlation with MAPK alterations and clinicopathological associations.Semantic proximity Read ↗

TRAIL-R2 is not correlated with p53 status and is rarely mutated in non-small cell lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.