Article
Frequent polymorphic changes but not mutations of TRAIL receptors DR4 and DR5 in mantle cell lymphoma and other B-cell lymphoid neoplasms.
Haematologica - 1 Nov 2004
Fernàndez Verònica, Jares Pedro, Beà Sílvia, Salaverria Itziar, Guino Elisabet, de Sanjosé Sílvia, Colomer Dolors, Ott German, Montserrat Emili, Campo Elias
Abstract excerpt
BACKGROUND AND OBJECTIVES: Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptors DR4 and DR5 have been mapped to chromosome 8p21-22, a region frequently deleted in different lymphoid neoplasms. DESIGN AND METHODS: To investigate the potential alterations of these genes in lymphoid neoplasms, we examined the presence of gene mutations in exons 3, 4, and 9 in 69 cases with mantle cell lymphoma...
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