Article
Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma.
Blood - 15 Dec 2007
Young Ken H, Weisenburger Dennis D, Dave Bhavana J, Smith Lynette, Sanger Warren, Iqbal Javeed, Campo Elias, Delabie Jan, Gascoyne Randy D, Ott German, Rimsza Lisa, Müller-Hermelink H Konrad, Jaffe Elaine S, Rosenwald Andreas, Staudt Louis M, Chan Wing C, Greiner Timothy C
Abstract excerpt
Mutations of the TP53 tumor suppressor gene have been associated with poor survival in some series of diffuse large B-cell lymphoma (DLBCL) but not in other studies. The purpose of this study was to identify the frequency of TP53 alterations (mutations or deletions), characterize the gene expression of mutant/deleted cases, and determine the effects of mutations on survival. In a series of DLBCL that had previous...
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