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Article

TRAIL-R2 is not correlated with p53 status and is rarely mutated in non-small cell lung cancer.

Anticancer research - 1 Jan 2000

Wu W G, Soria J C, Wang L, Kemp B L, Mao L

Abstract excerpt

BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors play an important role in regulating apoptosis. Recently, it was shown that the expression of TRAIL-R2, also known as KILLER, Trick or DR5, can be induced by either DNA damage or overexpression of a wild-type p53 transgene, suggesting a role for p53 in the death-signaling pathway. Furthermore, mutations in the death domain of...

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Share to Carcinoma, Non-Small-Cell Lung
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PMID: 11205299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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