Article
Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2001
Fisher M J, Virmani A K, Wu L, Aplenc R, Harper J C, Powell S M, Rebbeck T R, Sidransky D, Gazdar A F, El-Deiry W S
Abstract excerpt
Allelic loss of chromosome 8p21-22 occurs frequently in cancer, including lung and head and neck squamous cell cancer. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors, including proapoptotic DR4 and KILLER/DR5, are located on 8p21-22. TRAIL receptors are candidate tumor suppressor genes, because their inactivation would be expected to result in deficient apoptotic signaling. To...
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