Article
Functional implication of TRAIL -716 C/T promoter polymorphism on its in vitro and in vivo expression and the susceptibility to sporadic breast tumor.
Breast cancer research and treatment - 1 Apr 2011
Pal Ranjana, Gochhait Sailesh, Chattopadhyay Shilpi, Gupta Pawan, Prakash Neeraj, Agarwal Gaurav, Chaturvedi Arun, Husain Nuzhat, Husain Syed Akhtar, Bamezai Rameshwar N K
Abstract excerpt
Recently, TRAIL function has been elucidated beyond its known classical role of mediating cellular homeostasis and immune surveillance against transformed cells. Here, we show how CC genotype of -716 TRAIL promoter SNP rendered risk for sporadic breast cancer as compared to the CT and TT genotypes (P (recessive model) = 0.018, OR = 1.4, 95% CI = 1.1-1.9; P (allele model) = 0.010, OR = 1.3, 95% CI = 1.1-1.7). The...
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