Article
Comprehensive expression analysis of TNF-related apoptosis-inducing ligand and its receptors in colorectal cancer: Correlation with MAPK alterations and clinicopathological associations.
Pathology, research and practice - 1 Jun 2018
Tsikalakis Spyridon, Chatziandreou Ilenia, Michalopoulos Nikolaos V, Theodoropoulos Georgios E, Sakellariou Stratigoula, Korkolopoulou Penelope, Patsouris Efstratios, Saetta Angelica A
Abstract excerpt
TNF-related, apoptosis-inducing ligand (TRAIL) apoptotic pathway constitutes a promising therapeutic target due to high selectivity and low toxicity of TRAIL targeting agents when administered in combination therapies. 106 colorectal cancers were examined for: relative mRNA expression of TRAIL pathway genes, decoy receptors TRAIL-R3 and TRAIL-R4 promoter methylation and the presence of KRAS, NRAS, BRAF mutations....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.