The effect of marker characteristics on the power to detect linkage disequilibrium due to single or multiple ancestral mutations.

doi:10.1017/S0003480000008046

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Article

The effect of marker characteristics on the power to detect linkage disequilibrium due to single or multiple ancestral mutations.

Annals of human genetics - 1 Mar 2000

Sham P C, Zhao J H, Curtis D

Abstract excerpt

An important design issue in allelic association studies for mapping disease genes is the choice of markers. We have used a simple model of a founder population, similar to those of Ott & Rabinowitz (1997) and Chapman & Wijsman (1998), to explore the effect of the number of alleles at a marker po...

Topics

Chi-Square Distribution
Founder Effect
Humans
Linkage Disequilibrium
Mutation

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