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Article

Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro.

Nucleic acids research - 15 Oct 2002

Gavory Gérald, Farrow Mark, Balasubramanian Shankar

Abstract excerpt

Telomeres are essential for genomic stability and cell viability. Telomerase, the enzyme responsible for telomere maintenance, is composed of a reverse transcriptase protein subunit and an integral RNA component which contains the templating domain. In human telomerase, the template region consists of 11 nt (3'-rCAAUCCCAAUC-5') and comprises an alignment domain (italicised) plus a template sequence encoding the...

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Identifiers

PMID: 12384594
DOI: 10.1093/nar/gkf575
PMCID: PMC137139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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