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Article

Human telomerase RNA template sequence is a determinant of telomere repeat extension rate.

The Journal of biological chemistry - 23 Sept 2005

Drosopoulos William C, Direnzo Roberto, Prasad Vinayaka R

Abstract excerpt

Human telomerase is a specialized reverse transcriptase that utilizes an integral RNA subunit to template the synthesis of telomeres. In the present study, we demonstrate that the human telomerase template sequence not only determines the composition, but also the rate of synthesis, of telomere repeats. Mutagenesis of the template sequence identified variants that reconstitute enzymes with repeat extension rates...

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Identifiers

PMID: 16061476
DOI: 10.1074/jbc.M506319200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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