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Article

Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate.

The Journal of biological chemistry - 26 Dec 2003

Lee Suzanne R, Wong Judy M Y, Collins Kathleen

Abstract excerpt

The reverse transcriptase telomerase copies an internal RNA template to synthesize telomeric simple-sequence repeats. In the cellular context, telomerase must elongate its few intended substrates (authentic chromosome ends) without spurious activity on other potential substrates (chromosome ends created by damage, repair, or recombination). Many mechanisms have been proposed to account for the biological...

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PMID: 14565961
DOI: 10.1074/jbc.M311359200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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