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Article

Compound disruption of smad2 accelerates malignant progression of intestinal tumors in apc knockout mice.

Cancer research - 15 Oct 2002

Hamamoto Toshiaki, Beppu Hideyuki, Okada Hitoshi, Kawabata Masahiro, Kitamura Tadaichi, Miyazono Kohei, Kato Mitsuyasu

Abstract excerpt

Smad2 is a receptor-regulated Smad that is activated specifically by transforming growth factor beta and activin signaling. We disrupted the mouse Smad2 gene by gene targeting. Homozygous Smad2 mutant mice died around E8.5 with impaired visceral endoderm function and deficiency of mesoderm formation. Heterozygotes were fertile and had no apparent abnormality up to at least 1 1/2 year of age. To examine the role...

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Source

Identifiers

PMID: 12384562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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