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Article

Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice.

Human cell - 1 Sept 2000

Taketo M M, Takaku K

Abstract excerpt

The SMAD4 (Dpc4) gene plays a key role in the TGF-beta signaling pathway. We recently inactivated the mouse homolog Smad4. The homozygous mutants were embryonic lethals, whereas the heterozygotes were viable and fertile. Although young heterozygotes were normal, old mice developed gastric and duodenal polyps similar to those found in human juvenile polyps characterized by abundant stroma and eosinophilic...

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Source

Identifiers

PMID: 11197776

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice.PMID 11197776Read ↗

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Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in miceSemantic proximity Read ↗

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Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.Semantic proximity Read ↗

SMAD genes in juvenile polyposis.Semantic proximity Read ↗

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